As I read Dr Maxwell’s article about laboratory literature (Trinity 2014) I was disappointed not to see reference to a couple of very old friends. I was assigned in my science-oriented high school to read Sinclair Lewis’s Pulitzer-awarded 1925 novel Arrowsmith (Harcourt, Brace & Co). The anonymous writer of a Wikipedia article on this book says, ‘Arrowsmith is arguably the earliest major novel to deal with the culture of science.’ Although required to read and comment on it, I found it tragically compelling. And then, while in college, I read voluntarily CP Snow’s The Affair, a 1960 (MacMillan) member of his Strangers and Brothers series. Although the series was structured around the human conflict as seen in an Oxbridge college, the main plot device in The Affair was an investigation into alleged scientific fraud. Timely then and timely now.