The reasons you feel pain are much less straightforward than you may realise. Oxford researcher Lauren Heathcote probes the mystery.

Is pain always real?

By Lauren Heathcote

When I was fifteen, the pain started. At first it was mild, but soon there were constant shooting pains down my left leg. The MRI results were clear: a tumour in my pelvis. A big one. And it was pressing on my sciatic nerve. After a year of chemo and radiotherapy, the tumour shrunk and the pain went away.

Then something strange happened. A year later, the pain came back. But this time things were different. The tumour hadn’t regrown, and there were no new signs of cancer. I was told that the pain was probably caused by my fear of the cancer returning. It was right then I realised that pain is a mysterious creature. And science is now starting to uncover some of its mysteries.

A basic understanding of pain is that it tells us something’s wrong. You might think, and understandably so, that pain is the direct outcome of tissue damage. If I cut my finger, it hurts. If I cut it more, it hurts more. Right? Wrong. Contrary to popular belief, pain is not always a good indication of tissue damage. Pain is, in fact, a conscious output of the brain when an organism perceives tissue to be under threat. The key word here is perceives. It may perceive threat even when there is none. And it may ignore threat even when the threat is very real.

Our first clues came in the 1960s, when a Canadian researcher named Ronald Melzack, and an Oxford alum, Patrick Wall, conducted a series of animal experiments. They showed that rats displayed wildly different levels of pain behaviour but with the same level of tissue damage. That was clue number one.

Then they tested the nociceptors — free nerve endings all over (and inside) our bodies. These were, at least until the 60s, revered as the body’s ‘pain receptors’. Nociceptors are now better understood as the body’s danger detectors, sensing potential harm in the form of mechanical (pressure), thermal and chemical stimuli on the skin and inside the body. Melzack and Wall found that the level of nociception did not explain the rats’ level of pain behaviour. That was clue number two.

So for the rats, pain behaviour did not provide an accurate measure of tissue damage. And it soon became clear that the same is true for the feeling of pain in humans. Of course, anecdotal evidence has been providing clues for centuries. Think of the injured soldier, who feels no pain but keeps fighting. Think of the rugby player, who discovers his broken ankle only after the crowd has gone home. Clearly, in these situations, there is tissue damage. There is nociception — neural signalling of danger. But there is no pain.

In controlled laboratory settings, using healthy, normal volunteers — although (as leading researcher Lorimer Moseley has pointed out) just how ‘normal’ someone is who volunteers to be in a pain study is a reasonable question! — scientists have conducted experiments in which they simultaneously record activity in nociceptors and pain ratings. The evidence, once again, is that there is no straightforward relationship between tissue damage and pain.

Pain

So what does account for our feelings of pain? And why does the brain get it so wrong so often? In fact, the brain is actually doing something quite clever: using all of the available information to make a decision about the amount of threat to the tissues. This includes information not only from the nociceptors, but also from our other senses. And from data already stored within the brain itself.

In one study led by Lorimer Moseley at Oxford in 2007, a very cold piece of metal was placed on the back of volunteers’ hands—so cold that that it was likely to feel somewhat painful. At the same time, they were shown either a red or a blue light, but were told nothing about the light or its meaning. Amazingly, the volunteers reported more unpleasant and intense pain when they saw the red light than the blue light. This is because the brain used the information that red is a danger signal, and so produced a stronger danger signal of its own: more pain.

At fMRIB, the Oxford centre for functional magnetic resonance imaging of the brain, scientists are investigating how other types of information affect pain. Intriguingly, in a groundbreaking study just last week, the team identified for the first time a brain region that is seemingly pain-specific. However, this brain area is highly connected to other brain systems involved in memory and emotions such as fear and anxiety. And these systems talk to each other to decide how much pain to produce. So if you’re feeling anxious about having an injection, your brain will use this information as an indication of danger, and it will create more pain.

Chronic pain

Scientists are also now beginning to understand what happens when pain persists. Around one in ten people suffer from chronic pain, a condition that has received recent media attention from Jennifer Aniston’s new movie Cake. We now know that chronic pain disorders are caused by changes in the brain and central nervous system. As pain persists, the neural system dedicated to pain processing becomes increasingly sensitized, which means that the relationship between pain and the state of the tissues becomes weaker and less predictable. For these patients, pain is not a symptom of another disorder; pain is the disorder. But this doesn’t mean that the pain isn’t real. Remember, all pain is created by the brain. No brain, no pain.

And if you need more convincing that chronic pain isn’t caused by weak, ageing tissues, children get it too. My personal experience with pain has led me to specialise in researching the role of the brain and mind in children’s experience of pain. Alongside clinicians at the Nuffield Orthopaedic Centre here in Oxford, and thanks to a fellowship grant from the UK charity Action Medical Research, my supervisors and I are developing new interventions for young people with chronic pain. These interventions are based on our understanding of the psychology and neuroscience of pain, and are designed to help change how the brain processes cues for pain.

It’s been said that pain is weakness leaving the body. But pain isn’t a weakness, it’s your brain trying to protect your body, and using every piece of information to do so. And this is a pretty amazing feat for a 1.4kg spongy thing inside your head, even if it does sometimes get it wrong.

Lauren Heathcote matriculated at Magdalen in 2013 as a graduate student to pursue her DPhil with the Department of Experimental Psychology. She was a member of St Hugh’s College 2010–11 while completing her MSc in psychological research.

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Photograph of Lauren Heathcote reproduced by permission. Pain image by Steven Depolo via Flickr under Creative Commons licence.


 


Comments

By Sue Hodgson
on

Hi Lauren,
This is a great accessible summery of current knowledge of pain. I suffer from chronic pain and as I have a medical background I've become very interested in the neuroscience/psycology of pain. I will recommend others I know who suffer from chronic pain read this article to enable them to understand a little about pain mechanisms, so misunderstood by the general population. I often also find myself directing people to Lorimar Moseley's TED talk 'Why Things Hurt' - very entertaining as well as informative!
Thanks!
Sue.

By Lauren Heathcote
on

Thank you very much for your kind and positive comment, Sue.

By Jonathan Chiswe...
on

I have noticed that trips to the dentist are less painful of I consciously relax my hands(unclench the fists when lying back in the chair), and then when the drill starts, focus on slow deep breaths and imaging myself in a beautiful place. This really does reduce the pain.

By Jon Cook
on

Following on from Jonathan Chiswe - and in case it's of help to anyone:
Long ago, I decided that pain does not actually exist – it is all in the mind. This has worked pretty well for me over time, and despite having terrible teeth, I have not had an injection since 1963. So when drilling starts, I begin concentrating on something specific. For several years I used to focus on eating an apple which was quite effective, but I now go mentally shopping in our local supermarket. This works well as I have to cycle to get there, then go round the shop deciding what I want to buy. This technique has got me through 6 root canals and countless fillings. The pain is still there and can cause you to jump a bit, but is easily managed. I have asked my dentist a few times if he minds me not having a jab but he always says he is ok with it. At one level he prefers it, as he can instantly tell if he is getting into a sensitive area. The system works fine for short duration pain, like a visit to the dentist, but might not be so good for chronic pain - you can only shop for so long! But maybe some variant of the technique could be relevant.

By Peter Guild
on

A most interesting article - I was diagnosed with Fibromyalgia some 3 years ago - I l have learned that the best (and indeed only) true relief from the pain is the use of cognitive behavioural therapy whereby I simply dismiss the pain as being in the mind.

After considerable practice this has developed to such an extent that today I live pretty much pain free without having to think about it.

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